Verbalactone, a New Macrocyclic Dimer Lactone from the Roots of Verbascum undulatum with Antibacterial Activity

A novel macrocyclic dimer lactone, named verbalactone, was isolated from the roots of Verbascum undulatum and exhibited interesting antibacterial activity. It is the first time that 1,7-dioxacyclododecane is reported as the ring system of a natural product. The structure and the absolute stereochemi...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-08, Vol.64 (8), p.1093-1094
Main Authors: MAGIATIS, Prokopios, SPANAKIS, Dimitris, MITAKU, Sofia, TSITSA, Eugenia, MENTIS, Andreas, HARVALA, Catherine
Format: Article
Language:English
Subjects:
1,7-Dioxacyclododecane
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
Chromatography, Thin Layer
Decanoic Acids - chemistry
Decanoic Acids - pharmacology
Enterobacter aerogenes - drug effects
Escherichia coli - drug effects
General pharmacology
Greece
Klebsiella pneumoniae - drug effects
Lactobacillus casei - drug effects
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Microbial Sensitivity Tests
Molecular Conformation
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Roots - chemistry
Plants, Medicinal - chemistry
Pseudomonas aeruginosa - drug effects
Salmonella enteritidis - drug effects
Spectrophotometry, Infrared
Staphylococcus aureus - drug effects
Staphylococcus epidermidis - drug effects
Stereoisomerism
verbalactone
Verbascum undulatum
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Summary:A novel macrocyclic dimer lactone, named verbalactone, was isolated from the roots of Verbascum undulatum and exhibited interesting antibacterial activity. It is the first time that 1,7-dioxacyclododecane is reported as the ring system of a natural product. The structure and the absolute stereochemistry of the new compound were determined by spectral methods and chemical correlation.
ISSN:0163-3864
1520-6025
DOI:10.1021/np010025r