CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1

HIV-1 establishes a low-level persistent infection in astrocytes. In this study, we studied the susceptibility of a human astrocyte cell line (SVG-A) to infection with luciferase expressing reporter viruses pseudotyped with envelopes derived from five isolates of HIV-1. SVG-A cells were susceptible...

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Bibliographic Details
Published in:Journal of neurovirology 2001-04, Vol.7 (2), p.155-162
Main Author: Becky Schweighardt, Joseph Tc Shieh, Walter J Atwood
Format: Article
Language:English
Subjects:
AIDS Dementia Complex - immunology
AIDS Dementia Complex - virology
Astrocytes - cytology
Astrocytes - virology
CD4 antigen
CD4 Antigens - genetics
CD4 Antigens - immunology
Cell Line
CXCR4 protein
Fetus - cytology
Gene Expression - immunology
Genes, Reporter
HIV-1 - classification
HIV-1 - growth & development
Human immunodeficiency virus 1
Humans
Luciferases - genetics
Receptors, CXCR4 - genetics
Receptors, CXCR4 - immunology
RNA, Messenger - analysis
Serotyping
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Summary:HIV-1 establishes a low-level persistent infection in astrocytes. In this study, we studied the susceptibility of a human astrocyte cell line (SVG-A) to infection with luciferase expressing reporter viruses pseudotyped with envelopes derived from five isolates of HIV-1. SVG-A cells were susceptible to infection by a T-cell tropic isolate and the infection was both CD4 and CXCR4 independent. These data confirm the susceptibility of astrocytes to infection with T-tropic strains of HIV-1 and suggest a novel mechanism by which T-tropic strains of HIV can infect cells.
ISSN:1355-0284
1538-2443
DOI:10.1080/13550280152058816