Tissue factor expression and angiogenesis in human prostate carcinoma

In tumors, the switch to the angiogenic phenotype is thought to be controlled by a balance of positive and negative angiogenic factors. Tissue factor (TF) produced by tumor cells has been implicated in the regulation of this "angiogenic switch" through its ability to concurrently induce th...

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Bibliographic Details
Published in:Human pathology 2000-04, Vol.31 (4), p.443-447
Main Authors: ABDULKADIR, S. A, CARVALHAL, G. F, KALEEM, Z, KISIEL, W, HUMPHREY, P. A, CATALONA, W. J, MILBRANDT, J
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood supply
Adenocarcinoma - metabolism
Adenocarcinoma - surgery
Biological and medical sciences
Disease Progression
Humans
Immunohistochemistry
Male
Medical sciences
Microcirculation
Middle Aged
Neovascularization, Pathologic - pathology
Nephrology. Urinary tract diseases
Prostatic Neoplasms - blood supply
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - surgery
Thromboplastin - biosynthesis
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:In tumors, the switch to the angiogenic phenotype is thought to be controlled by a balance of positive and negative angiogenic factors. Tissue factor (TF) produced by tumor cells has been implicated in the regulation of this "angiogenic switch" through its ability to concurrently induce the expression of angiogenic molecules such as vascular endothelial cell growth factor (VEGF), while inhibiting the expression of anti-angiogenic molecules such as thrombospondin 2. We have examined TF expression and its relationship to angiogenesis and tumor progression in human prostate carcinomas. Most of the prostate carcinoma specimens examined (73%; n = 67) express high levels of TF. Immunohistochemical analysis localized TF expression to the epithelial cells of malignant glands. TF expression was significantly correlated with tumor angiogenesis as measured by the microvessel density (MVD). In addition, TF expression was correlated with the preoperative PSA level, a strong predictor of recurrence in prostate carcinomas. Our findings show that TF expression by the malignant glands in prostate cancer is common and suggest a role for this molecule in regulating prostate cancer progression and angiogenesis.
ISSN:0046-8177
1532-8392
DOI:10.1053/hp.2000.6547