Quantitative genetics and mouse behavior

Quantitative differences are observed for most complex behavioral and pharmacological traits within any population. Both environmental and genetic influences regulate such individual differences. The mouse has proven to be a superb model in which to investigate the genetic basis for quantitative dif...

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Bibliographic Details
Published in:Annual review of neuroscience 2001-01, Vol.24 (1), p.845-867
Main Authors: WEHNER, Jeanne M, RADCLIFFE, Richard A, BOWERS, Barbara J
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal
Behavioral psychophysiology
Biological and medical sciences
Brain - physiology
Fundamental and applied biological sciences. Psychology
Genetics
Humans
Learning
Memory
Mice - genetics
Mice - psychology
Miscellaneous
Models, Genetic
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
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Summary:Quantitative differences are observed for most complex behavioral and pharmacological traits within any population. Both environmental and genetic influences regulate such individual differences. The mouse has proven to be a superb model in which to investigate the genetic basis for quantitative differences in complex behaviors. Genetically defined populations of mice, including inbred strains, heterogeneous stocks, and selected lines, have been used effectively to document these genetic differences. Recently, quantitative trait loci methods have been applied to map the chromosomal regions that regulate variation with the goal of eventually identifying the gene polymorphisms that reside in these regions.
ISSN:0147-006X
1545-4126
DOI:10.1146/annurev.neuro.24.1.845