Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography

Homocysteine and vitamins B were correlated with coronary artery disease in patients undergoing diagnostic coronary angiography. 160 patients having > or =1 stenosis (G1), 55 patients having normal coronary arteries (G2) and 171 healthy volunteers (G3) were prospectively recruited. Homocysteine l...

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Bibliographic Details
Published in:Amino acids 2000, Vol.18 (2), p.139-146
Main Authors: Abdelmouttaleb, I, Danchin, N, Aimone-Gastin, I, Namour, F, Angioi, M, Gelot, M A, Bennani, N, Lambert, D, Jeandel, C, Guéant, J L
Format: Article
Language:English
Subjects:
Aged
Angiography
Arteries
Cardiovascular disease
Case-Control Studies
Coronary Angiography
Coronary artery
Coronary artery disease
Coronary Disease - diagnosis
Coronary vessels
Diagnostic systems
Female
Folic acid
Folic Acid - blood
Heart diseases
Homocysteine
Homocysteine - blood
Humans
Hyperhomocysteinemia
Male
Medical imaging
Middle Aged
Multivariate Analysis
Pyridoxine - blood
Risk Factors
Stenosis
Vitamin B 12 - blood
Vitamin B12
Vitamin B6
Vitamin deficiency
Vitamins
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Summary:Homocysteine and vitamins B were correlated with coronary artery disease in patients undergoing diagnostic coronary angiography. 160 patients having > or =1 stenosis (G1), 55 patients having normal coronary arteries (G2) and 171 healthy volunteers (G3) were prospectively recruited. Homocysteine levels were significantly higher in patients, particularly in those with normal coronary angiograms, than in healthy subjects (13.8 +/-6.3 micromol/L in G1 (p < 0.0001) and 15.2 +/- 8.8 micromol/L in G2 (p < 0.0001) versus 10.1 +/- 3.1 micromol/L in G3). Homocysteine levels were not related to the extent of coronary artery disease. In patients with normal angiogram, vitamin B12 and folate levels were significantly higher compared with the other groups (p < 0.05 and p < 0.001, respectively) showing that vitamin B deficiency was not involved in the hyperhomocysteinemia. In conclusion, homocysteine and vitamins B levels do not contribute to discriminate for the presence of coronary artery disease in patients undergoing diagnostic coronary angiography. Homocysteine levels, however, were higher in patients referred for coronary angiography than in healthy controls.
ISSN:0939-4451
1438-2199
DOI:10.1007/s007260050012