Anticancer and Some Biological Activities of Thiazinotrienomycin B

As a primary screening system for new anticancer antibiotics, we have been using several cancer cell lines of human origins and selecting microbial products that are growth-inhibitory in vitro to certain cell lines, rather than to all the cell lines, to avoid compounds of nonspecific toxicity. Thiaz...

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Bibliographic Details
Published in:Journal of antibiotics 2000/03/25, Vol.53(3), pp.306-308
Main Authors: HOSOKAWA, NOBUO, IINUMA, HIRONOBU, TAKEUCHI, TOMIO, SATO, SHIGEO, YAMORI, TAKAO, TSUCHIYA, KAYOKO S., HORI, MAKOTO
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - pharmacology
Antineoplastic agents
Biological and medical sciences
Cell Division - drug effects
General aspects
Graft Survival - drug effects
Humans
Medical sciences
Mice
Mice, Nude
Neoplasm Transplantation
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - pathology
Pharmacology. Drug treatments
Random Allocation
Thiazines - pharmacology
thiazinotrienomycin B
Transplantation, Heterologous
Tumor Cells, Cultured - drug effects
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Summary:As a primary screening system for new anticancer antibiotics, we have been using several cancer cell lines of human origins and selecting microbial products that are growth-inhibitory in vitro to certain cell lines, rather than to all the cell lines, to avoid compounds of nonspecific toxicity. Thiazinotrienomycins were isolated for their activities somewhat specific to HeLa than to other cell lines which were available to us at the time of our investigation. Thiazinotrienomycin B (referred to as TT-B), a minor member in quantity, turned out to be the strongest in inhibiting growth in vitro of HeLa cells. In the present paper, we report the pattern of differential growth inhibition in vitro by TT-B of a disease-oriented panel of human tumor cell lines and the inhibition by TT-B of xenograft of BSY-1 (breast) in nude mice.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.306