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Anticancer and Some Biological Activities of Thiazinotrienomycin B

As a primary screening system for new anticancer antibiotics, we have been using several cancer cell lines of human origins and selecting microbial products that are growth-inhibitory in vitro to certain cell lines, rather than to all the cell lines, to avoid compounds of nonspecific toxicity. Thiaz...

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Published in:	Journal of antibiotics 2000/03/25, Vol.53(3), pp.306-308
Main Authors:	HOSOKAWA, NOBUO, IINUMA, HIRONOBU, TAKEUCHI, TOMIO, SATO, SHIGEO, YAMORI, TAKAO, TSUCHIYA, KAYOKO S., HORI, MAKOTO
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Language:	English
Subjects:	Animals Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Cell Division - drug effects General aspects Graft Survival - drug effects Humans Medical sciences Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Pharmacology. Drug treatments Random Allocation Thiazines - pharmacology thiazinotrienomycin B Transplantation, Heterologous Tumor Cells, Cultured - drug effects
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container_title	Journal of antibiotics
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creator	HOSOKAWA, NOBUO IINUMA, HIRONOBU TAKEUCHI, TOMIO SATO, SHIGEO YAMORI, TAKAO TSUCHIYA, KAYOKO S. HORI, MAKOTO
description	As a primary screening system for new anticancer antibiotics, we have been using several cancer cell lines of human origins and selecting microbial products that are growth-inhibitory in vitro to certain cell lines, rather than to all the cell lines, to avoid compounds of nonspecific toxicity. Thiazinotrienomycins were isolated for their activities somewhat specific to HeLa than to other cell lines which were available to us at the time of our investigation. Thiazinotrienomycin B (referred to as TT-B), a minor member in quantity, turned out to be the strongest in inhibiting growth in vitro of HeLa cells. In the present paper, we report the pattern of differential growth inhibition in vitro by TT-B of a disease-oriented panel of human tumor cell lines and the inhibition by TT-B of xenograft of BSY-1 (breast) in nude mice.
doi_str_mv	10.7164/antibiotics.53.306
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subjects	Animals Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Cell Division - drug effects General aspects Graft Survival - drug effects Humans Medical sciences Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Pharmacology. Drug treatments Random Allocation Thiazines - pharmacology thiazinotrienomycin B Transplantation, Heterologous Tumor Cells, Cultured - drug effects
title	Anticancer and Some Biological Activities of Thiazinotrienomycin B
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