Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy

To determine whether inflammatory cytokines are increased in proliferative diabetic retinopathy. We measured concentrations of interleukin-6, 8 (IL-6, 8) and tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay (ELISA) in vitreous and serum from 47 patients with proliferative diabetic...

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Published in:Journal of diabetes and its complications 2001-09, Vol.15 (5), p.257-259
Main Authors: Yuuki, Takashi, Kanda, Tsugiyasu, Kimura, Yasutaka, Kotajima, Nobuo, Tamura, Jun'ichi, Kobayashi, Isao, Kishi, Shoji
Format: Article
Language:English
Subjects:
Associated diseases and complications
Biological and medical sciences
Blood - metabolism
Cytokine
Cytokines - metabolism
Diabetes. Impaired glucose tolerance
Diabetic Retinopathy - metabolism
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Humans
Inflammation Mediators - metabolism
Interleukin-6 - metabolism
Interleukin-8
Interleukin-8 - metabolism
Medical sciences
Retinopathy
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
Vitreoretinopathy, Proliferative - metabolism
Vitreous Body - metabolism
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Summary:To determine whether inflammatory cytokines are increased in proliferative diabetic retinopathy. We measured concentrations of interleukin-6, 8 (IL-6, 8) and tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay (ELISA) in vitreous and serum from 47 patients with proliferative diabetic retinopathy and 21 patients with vitreous noninflammatory retinopathies. Vitreous concentration of IL-6 were 64.7±12.8 pg/ml in proliferative diabetic retinopathy, much greater ( P
ISSN:1056-8727
1873-460X
DOI:10.1016/S1056-8727(01)00155-6