Estimation of skeletal muscle interstitial adenosine during forearm dynamic exercise in humans

It has been proposed that adenosine is a metabolic signal that triggers activation of muscle afferents involved in the exercise pressor reflex. Furthermore, exogenous adenosine induces sympathetic activation that mimics the exercise pressor reflex, and blockade of adenosine receptors inhibits sympat...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-05, Vol.35 (5), p.1124-1128
Main Authors: Costa, F., Heusinkveld, J., Ballog, R., Davis, S., Biaggioni, I.
Format: Article
Language:English
Subjects:
Adenosine - physiology
Adult
Biological and medical sciences
Exercise
Female
Forearm
Fundamental and applied biological sciences. Psychology
Humans
Lactic Acid
Life Sciences (General)
Male
Microdialysis
Muscle Contraction - physiology
Muscle, Skeletal - physiology
Reflex
Space life sciences
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:It has been proposed that adenosine is a metabolic signal that triggers activation of muscle afferents involved in the exercise pressor reflex. Furthermore, exogenous adenosine induces sympathetic activation that mimics the exercise pressor reflex, and blockade of adenosine receptors inhibits sympathetic activation induced by exercise. Thus, we hypothesize that adenosine is released locally by the muscle during exercise. We used microdialysis probes, placed in the flexor digitorium superficialis muscle, to estimate muscle interstitial adenosine levels in humans. We estimated resting in vivo muscle interstitial adenosine concentrations (0.292+/-0.058 micromol/L, n=4) by perfusing increasing concentrations of adenosine to determine the gradient produced in the dialysate. Muscle interstitial adenosine concentrations increased from 0.23+/-0.04 to 0.82+/-0.14 micromol/L (n=14, P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.35.5.1124