The use of near-infrared spectroscopy to monitor the mobility of water within the sarafloxacin crystal lattice

Near-infrared spectroscopy (NIRS) is proposed as a technique to study the mobility of water within the sarafloxacin crystal lattice. An investigation of two samples of sarafloxacin revealed that NIRS can distinguish between acceptable and unacceptable batches for formulation purposes. X-ray powder d...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2000-06, Vol.22 (5), p.829-848
Main Authors: Dziki, Walter, Bauer, John F, Szpylman, Joseph J, Quick, John E, Nichols, Brian C
Format: Article
Language:English
Subjects:
Analysis
Anti-Infective Agents - chemistry
Biological and medical sciences
Calorimetry, Differential Scanning
Ciprofloxacin - analogs & derivatives
Ciprofloxacin - chemistry
Crystallography, X-Ray
Fluoroquinolones
General pharmacology
Medical sciences
Near-infrared spectroscopy
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Sarafloxacin
Spectroscopy, Near-Infrared - methods
Water - chemistry
Water mobility
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Summary:Near-infrared spectroscopy (NIRS) is proposed as a technique to study the mobility of water within the sarafloxacin crystal lattice. An investigation of two samples of sarafloxacin revealed that NIRS can distinguish between acceptable and unacceptable batches for formulation purposes. X-ray powder diffraction (XRPD), mid-infrared (mid-IR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) could not detect any differences between the two samples. NIRS detected differences in the location or orientation of the water molecules within the crystal lattices.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(00)00247-8