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Intrahepatic MxA expression is correlated with interferon-alpha expression in chronic and fulminant hepatitis
Interferon‐alpha (IFN‐α) has potent pro‐inflammatory and anti‐viral functions. It exerts its effects by inducing intracellular proteins such as MxA. To analyse the role of intrahepatic interferon activation, IFN‐α and MxA expression was studied by immunohistochemistry in explant livers of 20 patient...
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| Published in: | The Journal of pathology 2001-08, Vol.194 (4), p.478-483 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c3853-a0b3442a7672e1fd49ad3215730db337c5a6c981321b7769c72a008d23bc93f13 |
| container_end_page | 483 |
| container_issue | 4 |
| container_start_page | 478 |
| container_title | The Journal of pathology |
| container_volume | 194 |
| creator | Leifeld, Ludger Ramakers, Jan Maria Schneiders, Angelika Ludwig Dumoulin, Franz Sterneck, Martina Müller, Andreas Sauerbruch, Tilman Spengler, Ulrich |
| description | Interferon‐alpha (IFN‐α) has potent pro‐inflammatory and anti‐viral functions. It exerts its effects by inducing intracellular proteins such as MxA. To analyse the role of intrahepatic interferon activation, IFN‐α and MxA expression was studied by immunohistochemistry in explant livers of 20 patients with fulminant hepatic failure (FHF), 41 patients with chronic liver disease (CLD), and ten normal controls (NCs). In NCs only small numbers of Kupffer cells, but no hepatocytes, showed IFN‐α and MxA expression. In contrast, significantly enhanced numbers of IFN‐α‐ and MxA‐positive Kupffer cells, along with small numbers of MxA‐positive and larger numbers of IFN‐α‐positive lymphocytes, were found in CLD and in FHF. MxA protein was also expressed on hepatocytes and bile ducts in the vicinity of IFN‐α‐positive inflammatory infiltrates (hepatocytes: NCs: 0%, CLD: 8%, FHF: 68%; bile ducts: NCs: 19%, CLD: 46%, FHF: 83%). A significant correlation was found between the numbers of IFN‐α‐ and MxA‐positive cells (r=0.67, p |
| doi_str_mv | 10.1002/path.903 |
| format | article |
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It exerts its effects by inducing intracellular proteins such as MxA. To analyse the role of intrahepatic interferon activation, IFN‐α and MxA expression was studied by immunohistochemistry in explant livers of 20 patients with fulminant hepatic failure (FHF), 41 patients with chronic liver disease (CLD), and ten normal controls (NCs). In NCs only small numbers of Kupffer cells, but no hepatocytes, showed IFN‐α and MxA expression. In contrast, significantly enhanced numbers of IFN‐α‐ and MxA‐positive Kupffer cells, along with small numbers of MxA‐positive and larger numbers of IFN‐α‐positive lymphocytes, were found in CLD and in FHF. MxA protein was also expressed on hepatocytes and bile ducts in the vicinity of IFN‐α‐positive inflammatory infiltrates (hepatocytes: NCs: 0%, CLD: 8%, FHF: 68%; bile ducts: NCs: 19%, CLD: 46%, FHF: 83%). A significant correlation was found between the numbers of IFN‐α‐ and MxA‐positive cells (r=0.67, p<0.001). Thus, large amounts of IFN‐α are released in the livers of patients with FHF, which is likely to contribute to immune‐mediated liver cell damage. Intrahepatic MxA expression corresponds to IFN‐α produced particularly by infiltrating inflammatory cells, rather than by hepatocytes themselves. Copyright © 2001 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.903</identifier><identifier>PMID: 11523057</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Antiviral Agents - metabolism ; Bile Ducts, Intrahepatic - metabolism ; Biological and medical sciences ; fulminant hepatitis ; Gastroenterology. Liver. Pancreas. Abdomen ; GTP-Binding Proteins ; Hepatitis, Chronic - metabolism ; Hepatitis, Viral, Human - metabolism ; Hepatocytes - metabolism ; Humans ; Immunoenzyme Techniques ; interferon-alpha ; Interferon-alpha - metabolism ; Liver Failure - metabolism ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Macrophages - metabolism ; Medical sciences ; MxA ; Myxovirus Resistance Proteins ; Other diseases. Semiology ; Proteins - metabolism</subject><ispartof>The Journal of pathology, 2001-08, Vol.194 (4), p.478-483</ispartof><rights>Copyright © 2001 John Wiley & Sons, Ltd.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3853-a0b3442a7672e1fd49ad3215730db337c5a6c981321b7769c72a008d23bc93f13</citedby><cites>FETCH-LOGICAL-c3853-a0b3442a7672e1fd49ad3215730db337c5a6c981321b7769c72a008d23bc93f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14068758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11523057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leifeld, Ludger</creatorcontrib><creatorcontrib>Ramakers, Jan</creatorcontrib><creatorcontrib>Maria Schneiders, Angelika</creatorcontrib><creatorcontrib>Ludwig Dumoulin, Franz</creatorcontrib><creatorcontrib>Sterneck, Martina</creatorcontrib><creatorcontrib>Müller, Andreas</creatorcontrib><creatorcontrib>Sauerbruch, Tilman</creatorcontrib><creatorcontrib>Spengler, Ulrich</creatorcontrib><title>Intrahepatic MxA expression is correlated with interferon-alpha expression in chronic and fulminant hepatitis</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>Interferon‐alpha (IFN‐α) has potent pro‐inflammatory and anti‐viral functions. It exerts its effects by inducing intracellular proteins such as MxA. To analyse the role of intrahepatic interferon activation, IFN‐α and MxA expression was studied by immunohistochemistry in explant livers of 20 patients with fulminant hepatic failure (FHF), 41 patients with chronic liver disease (CLD), and ten normal controls (NCs). In NCs only small numbers of Kupffer cells, but no hepatocytes, showed IFN‐α and MxA expression. In contrast, significantly enhanced numbers of IFN‐α‐ and MxA‐positive Kupffer cells, along with small numbers of MxA‐positive and larger numbers of IFN‐α‐positive lymphocytes, were found in CLD and in FHF. MxA protein was also expressed on hepatocytes and bile ducts in the vicinity of IFN‐α‐positive inflammatory infiltrates (hepatocytes: NCs: 0%, CLD: 8%, FHF: 68%; bile ducts: NCs: 19%, CLD: 46%, FHF: 83%). A significant correlation was found between the numbers of IFN‐α‐ and MxA‐positive cells (r=0.67, p<0.001). Thus, large amounts of IFN‐α are released in the livers of patients with FHF, which is likely to contribute to immune‐mediated liver cell damage. Intrahepatic MxA expression corresponds to IFN‐α produced particularly by infiltrating inflammatory cells, rather than by hepatocytes themselves. Copyright © 2001 John Wiley & Sons, Ltd.</description><subject>Antiviral Agents - metabolism</subject><subject>Bile Ducts, Intrahepatic - metabolism</subject><subject>Biological and medical sciences</subject><subject>fulminant hepatitis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>GTP-Binding Proteins</subject><subject>Hepatitis, Chronic - metabolism</subject><subject>Hepatitis, Viral, Human - metabolism</subject><subject>Hepatocytes - metabolism</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>interferon-alpha</subject><subject>Interferon-alpha - metabolism</subject><subject>Liver Failure - metabolism</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Macrophages - metabolism</subject><subject>Medical sciences</subject><subject>MxA</subject><subject>Myxovirus Resistance Proteins</subject><subject>Other diseases. Semiology</subject><subject>Proteins - metabolism</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp10F2L1DAUBuAgijuugr9AcqN40zUfTdNcDoPuLOz6sax4GU7TlEbbtCYZdvbfm6HFxQuvDpzz8B54EXpNyQUlhH2YIfUXivAnaEOJqgpVq-op2uQTK3hJ5Rl6EeNPQohSQjxHZ5QKxomQGzRe-RSgtznBGXxz3GJ7nION0U0eu4jNFIIdINkW37vUY-eTDZ0Nky9gmHv4h3ts-nzJQeBb3B2G0XnwCS_xycWX6FkHQ7Sv1nmOvn_6eLfbF9dfLq922-vC8FrwAkjDy5KBrCSztGtLBS1nVEhO2oZzaQRURtU07xopK2UkA0LqlvHGKN5Rfo7eLblzmH4fbEx6dNHYYQBvp0PUklJW0foE3y_QhCnGYDs9BzdCeNCU6FO1-lStztVm-mbNPDSjbR_h2mUGb1cA0cDQBfDGxUdXkqqWos6uWNy9G-zDfx_qr9u7_fJ49S4me_zrIfzSleRS6B-fL_UN5_z2drfX3_gfKRCgKQ</recordid><startdate>200108</startdate><enddate>200108</enddate><creator>Leifeld, Ludger</creator><creator>Ramakers, Jan</creator><creator>Maria Schneiders, Angelika</creator><creator>Ludwig Dumoulin, Franz</creator><creator>Sterneck, Martina</creator><creator>Müller, Andreas</creator><creator>Sauerbruch, Tilman</creator><creator>Spengler, Ulrich</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200108</creationdate><title>Intrahepatic MxA expression is correlated with interferon-alpha expression in chronic and fulminant hepatitis</title><author>Leifeld, Ludger ; Ramakers, Jan ; Maria Schneiders, Angelika ; Ludwig Dumoulin, Franz ; Sterneck, Martina ; Müller, Andreas ; Sauerbruch, Tilman ; Spengler, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3853-a0b3442a7672e1fd49ad3215730db337c5a6c981321b7769c72a008d23bc93f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antiviral Agents - metabolism</topic><topic>Bile Ducts, Intrahepatic - metabolism</topic><topic>Biological and medical sciences</topic><topic>fulminant hepatitis</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>GTP-Binding Proteins</topic><topic>Hepatitis, Chronic - metabolism</topic><topic>Hepatitis, Viral, Human - metabolism</topic><topic>Hepatocytes - metabolism</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>interferon-alpha</topic><topic>Interferon-alpha - metabolism</topic><topic>Liver Failure - metabolism</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Macrophages - metabolism</topic><topic>Medical sciences</topic><topic>MxA</topic><topic>Myxovirus Resistance Proteins</topic><topic>Other diseases. Semiology</topic><topic>Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leifeld, Ludger</creatorcontrib><creatorcontrib>Ramakers, Jan</creatorcontrib><creatorcontrib>Maria Schneiders, Angelika</creatorcontrib><creatorcontrib>Ludwig Dumoulin, Franz</creatorcontrib><creatorcontrib>Sterneck, Martina</creatorcontrib><creatorcontrib>Müller, Andreas</creatorcontrib><creatorcontrib>Sauerbruch, Tilman</creatorcontrib><creatorcontrib>Spengler, Ulrich</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leifeld, Ludger</au><au>Ramakers, Jan</au><au>Maria Schneiders, Angelika</au><au>Ludwig Dumoulin, Franz</au><au>Sterneck, Martina</au><au>Müller, Andreas</au><au>Sauerbruch, Tilman</au><au>Spengler, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrahepatic MxA expression is correlated with interferon-alpha expression in chronic and fulminant hepatitis</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2001-08</date><risdate>2001</risdate><volume>194</volume><issue>4</issue><spage>478</spage><epage>483</epage><pages>478-483</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>Interferon‐alpha (IFN‐α) has potent pro‐inflammatory and anti‐viral functions. It exerts its effects by inducing intracellular proteins such as MxA. To analyse the role of intrahepatic interferon activation, IFN‐α and MxA expression was studied by immunohistochemistry in explant livers of 20 patients with fulminant hepatic failure (FHF), 41 patients with chronic liver disease (CLD), and ten normal controls (NCs). In NCs only small numbers of Kupffer cells, but no hepatocytes, showed IFN‐α and MxA expression. In contrast, significantly enhanced numbers of IFN‐α‐ and MxA‐positive Kupffer cells, along with small numbers of MxA‐positive and larger numbers of IFN‐α‐positive lymphocytes, were found in CLD and in FHF. MxA protein was also expressed on hepatocytes and bile ducts in the vicinity of IFN‐α‐positive inflammatory infiltrates (hepatocytes: NCs: 0%, CLD: 8%, FHF: 68%; bile ducts: NCs: 19%, CLD: 46%, FHF: 83%). A significant correlation was found between the numbers of IFN‐α‐ and MxA‐positive cells (r=0.67, p<0.001). Thus, large amounts of IFN‐α are released in the livers of patients with FHF, which is likely to contribute to immune‐mediated liver cell damage. Intrahepatic MxA expression corresponds to IFN‐α produced particularly by infiltrating inflammatory cells, rather than by hepatocytes themselves. Copyright © 2001 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11523057</pmid><doi>10.1002/path.903</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of pathology, 2001-08, Vol.194 (4), p.478-483 |
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| language | eng |
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| source | Wiley |
| subjects | Antiviral Agents - metabolism Bile Ducts, Intrahepatic - metabolism Biological and medical sciences fulminant hepatitis Gastroenterology. Liver. Pancreas. Abdomen GTP-Binding Proteins Hepatitis, Chronic - metabolism Hepatitis, Viral, Human - metabolism Hepatocytes - metabolism Humans Immunoenzyme Techniques interferon-alpha Interferon-alpha - metabolism Liver Failure - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Macrophages - metabolism Medical sciences MxA Myxovirus Resistance Proteins Other diseases. Semiology Proteins - metabolism |
| title | Intrahepatic MxA expression is correlated with interferon-alpha expression in chronic and fulminant hepatitis |
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