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Effect of chronic protein restriction on motor co-ordination and brain neurotransmitters in albino rats

In this study we evaluated the motor co-ordination in Wistar strain albino rats that were maintained on a protein-restricted diet for a period of 1 year immediately after the weaning period, by substituting 75% of the normal diet with a carbohydrate-rich diet deficient in protein, for a period of 1...

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Bibliographic Details
Published in:Food and chemical toxicology 2001-10, Vol.39 (10), p.1039-1043
Main Authors: Mathangi, D.C., Namasivayam, A.
Format: Article
Language:English
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Summary:In this study we evaluated the motor co-ordination in Wistar strain albino rats that were maintained on a protein-restricted diet for a period of 1 year immediately after the weaning period, by substituting 75% of the normal diet with a carbohydrate-rich diet deficient in protein, for a period of 1 year immediately after the weaning period. This type of chronic protein restriction caused disturbances in motor co-ordination. It also caused a significant reduction in the basal levels of dopamine, norepinephrine, epinephrine and serotonin along with their metabolites homovanillic acid (HVA), vanillyl mandelic acid (VMA) and 5-hydroxy indoleacetic acid (5HIAA) and precursor l-dopa in the corpus striatum and cerebellum. Changes in these neurotransmitters could have caused altered co-ordination in the protein-restricted animals.
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(01)00051-5