The effect of growth hormone on the proliferation of human Th cell clones

The effects of human growth hormone (hGH) on human Th cell clones were examined. Both 20K and 22K hGH stimulated the proliferation of Th2 and Th0 cells in the presence of mite antigen, whereas they did not stimulate the proliferation of Th1 cells. Because the effect of 20K hGH was almost the same as...

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Bibliographic Details
Published in:Life sciences (1973) 2000-04, Vol.66 (20), p.1929-1935
Main Authors: Yamashita, Naomi, Hashimoto, Yoshihide, Honjo, Masaru, Yamashita, Naohide
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - pharmacology
Cell Division - drug effects
Cells, Cultured
Clone Cells
Culture Media, Conditioned - chemistry
Enzyme-Linked Immunosorbent Assay
growth hormone
growth hormone receptors
human growth hormone
Human Growth Hormone - analysis
Human Growth Hormone - pharmacology
Humans
Insect Proteins - immunology
Lymphocyte Activation
Mites - immunology
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - drug effects
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Helper-Inducer - cytology
T-Lymphocytes, Helper-Inducer - drug effects
T-Lymphocytes, Helper-Inducer - immunology
Th0
Th1
Th2
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Summary:The effects of human growth hormone (hGH) on human Th cell clones were examined. Both 20K and 22K hGH stimulated the proliferation of Th2 and Th0 cells in the presence of mite antigen, whereas they did not stimulate the proliferation of Th1 cells. Because the effect of 20K hGH was almost the same as that of 22KhGH, it was suggested that the action of hGH was not mediated through prolactin receptor but through hGH receptors. The application of growth hormone binding protein (GHBP) inhibited the cell growth of Th1 clones. In Th2 and Th0 cells GHBP inihibited the hGH-stimulated cell proliferation. However, GHBP alone did not affect the proliferation of Th2 and Th0 cells. Hgh was detected in the supernatant of Th1 clones in the presence of mite antigen but it was not detected in Th2 clones. Hgh was detected in one out of 4 batches of Th0 clones. These data indicated that hGH was secreted from Th1 clones, and that Th0 clones possessed characteristics of both Th2 and Th0 clones.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(00)00518-X