Assessment of coronary arterial restenosis with phase-contrast magnetic resonance imaging measurements of coronary flow reserve

After successful percutaneous coronary arterial revascularization, 25% to 60% of subjects have restenosis, a recurrent coronary arterial narrowing at the site of the intervention. At present, restenosis is usually detected invasively with contrast coronary angiography. This study was performed to de...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2000-05, Vol.101 (20), p.2375-2381
Main Authors: Hundley, W G, Hillis, L D, Hamilton, C A, Applegate, R J, Herrington, D M, Clarke, G D, Braden, G A, Thomas, M S, Lange, R A, Peshock, R M, Link, K M
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Flow Velocity
Coronary Angiography
Coronary Circulation
Coronary Disease - diagnosis
Coronary Disease - physiopathology
Coronary Vessels - physiopathology
Diagnosis, Computer-Assisted
Female
Humans
Magnetic Resonance Imaging - methods
Male
Middle Aged
Recurrence
Space life sciences
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Summary:After successful percutaneous coronary arterial revascularization, 25% to 60% of subjects have restenosis, a recurrent coronary arterial narrowing at the site of the intervention. At present, restenosis is usually detected invasively with contrast coronary angiography. This study was performed to determine if phase-contrast MRI (PC-MRI) could be used to detect restenosis noninvasively in patients with recurrent chest pain after percutaneous revascularization. Seventeen patients (15 men, 2 women, age 36 to 77 years) with recurrent chest pain >3 months after successful percutaneous intervention underwent PC-MRI measurements of coronary artery flow reserve followed by assessments of stenosis severity with computer-assisted quantitative coronary angiography. The intervention was performed in the left anterior descending coronary artery in 15 patients, one of its diagonal branches in 2 patients, and the right coronary artery in 1 patient. A PC-MRI coronary flow reserve value /=70% and >/=50%, respectively. Assessments of coronary flow reserve with PC-MRI can be used to identify flow-limiting stenoses (luminal diameter narrowings >70%) in patients with recurrent chest pain in the months after a successful percutaneous intervention.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.101.20.2375