Estimates of repolarization and its dispersion from electrocardiographic measurements: Direct epicardial assessment in the canine heart

This study investigates a technique to estimate dispersion based on the root mean square (RMS) signal of multiple electrocardiographic leads. Activation and recovery times were measured from 64 sites on the epicardium of canine hearts using acute in situ or Langendorff perfused isolated heart prepar...

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Bibliographic Details
Published in:Journal of electrocardiology 2000-04, Vol.33 (2), p.171-180
Main Authors: Fuller, Marc S., Sándor, György, Punske, Bonnie, Taccardi, Bruno, MacLeod, Rob S., Ershler, Phillip R., Green, Larry S., Lux, Robert L.
Format: Article
Language:English
Subjects:
activation
Animals
Biological and medical sciences
Cardiac Pacing, Artificial
Dogs
Electrocardiography
Electrocardiography. Vectocardiography
Electrodiagnosis. Electric activity recording
Electrophysiology
In Vitro Techniques
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Pericardium - physiology
QT dispersion
recovery
repolarization dispersion
RMS curve
Signal Processing, Computer-Assisted
Temperature
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Summary:This study investigates a technique to estimate dispersion based on the root mean square (RMS) signal of multiple electrocardiographic leads. Activation and recovery times were measured from 64 sites on the epicardium of canine hearts using acute in situ or Langendorff perfused isolated heart preparations. Repolarization and its dispersion were altered by varying cycle length, myocardial temperature, or ventricular pacing site. Mean and dispersion of activation and recovery times, and activation-recovery interval (ARI) were calculated for each beat. The waveform was then calculated from all leads. Estimates of mean and dispersion of activation and recovery times and mean ARI were derived using only inflection points from the RMS waveform. QT intervals were also measured and QT dispersion was determined. Estimates determined from the RMS waveform provided accurate estimates of repolarization and were, in particular, a better measure of repolarization dispersion than QT dispersion.
ISSN:0022-0736
1532-8430
DOI:10.1016/S0022-0736(00)80073-4