Predominance of Class II papG Allele of Escherichia coli in Pyelonephritis in Infants with Normal Urinary Tract Anatomy

P-fimbrial genotypes of Escherichia coli strains and their possible association with urinary tract abnormalities were studied in infants with pyelonephritis. A total of 153 urinary E. coli strains were analyzed by polymerase chain reaction for class I, II, and III alleles of the pyelonephritis-assoc...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-05, Vol.181 (5), p.1822-1824
Main Authors: Jantunen, M. E., Siitonen, A., Koskimies, O., Wikström, S., Kärkkäinen, UM, Salo, E., Saxén, H.
Format: Article
Language:English
Subjects:
Adhesins, Escherichia coli - genetics
Alleles
Bacteriology
Biological and medical sciences
Child health services
Children
Concise Communications
Escherichia coli
Escherichia coli - genetics
Escherichia coli Infections - microbiology
Female
Fimbriae Proteins
Fimbriae, Bacterial - genetics
Fundamental and applied biological sciences. Psychology
Genetics
Humans
Infant
Infants
Male
Microbiology
papG gene
Polymerase Chain Reaction
Pyelonephritis
Pyelonephritis - microbiology
Radiology
Reference Values
Urinary tract
Urinary Tract - anatomy & histology
Urinary tract infections
Vesico ureteral reflux
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Summary:P-fimbrial genotypes of Escherichia coli strains and their possible association with urinary tract abnormalities were studied in infants with pyelonephritis. A total of 153 urinary E. coli strains were analyzed by polymerase chain reaction for class I, II, and III alleles of the pyelonephritis-associated adhesin gene papG. Strains with any class II papG alleles were found significantly more often in infants with normal anatomy and function or in infants with clinically insignificant abnormalities than they were in infants with significant abnormalities (90 of 119 vs. 14 of 34 infants; P < .001). On the other hand, strains without any papG alleles were found significantly more often in infants with major urinary tract abnormalities (11 of 34 vs. 17 of 119 infants; P = .016). Our genotypic findings indicate that, especially in infants with a normal urinary tract, infection is caused by more-virulent E. coli than is present in infants without a normal urinary tract. This virulence could be due to expression of pyelonephritogenic P fimbriae by an infecting E. coli strain.
ISSN:0022-1899
1537-6613
DOI:10.1086/315446