The in-vitro and in-vivo characterization of PLGA:L-PLA microspheres containing dexamethasone sodium phosphate

• Published in: Journal of microencapsulation 2001, Vol.18 (5), p.603-612
• Main Authors: Eroglu, H, Kas, H S, Oner, L, Tuerkoglu, O F, Akalan, N, Sargon, M F, Oezer, N
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Brain - drug effects; Brain - metabolism; Brain Edema - drug therapy; Brain Edema - metabolism; Dexamethasone - administration & dosage; Dexamethasone - analogs & derivatives; Dexamethasone - chemistry; Dexamethasone Sodium Phosphate Microspheres Brain Oedema Plga L-PLA; General pharmacology; Lactic Acid - administration & dosage; Lipid Peroxidation; Medical sciences; Microspheres; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polyesters; Polyglycolic Acid - administration & dosage; Polymers - administration & dosage; Rats; Solubility
• ISSN: 0265-2048; 1464-5246
• DOI: 10.1080/02652040010019587

Dexamethasone sodium phosphate (DSP) is a widely used corticosteroid in the treatment of brain oedema associated with brain tumours. DSP has many side effects that limit its usage at an effective concentration. The objective of this study was to minimize these side effects by encapsulating DSP using biodegradable synthetic polymers, to extend the release time from microspheres and to evaluate the effectiveness in the treatment of brain oedema. Microspheres containing 5% DSP were formulated by the solvent evaporation method by using a 1:1 mixture of two synthetic polymers, poly(lactic-co-glycolic acid) and L-polylactic acid (PLGA and L-PLA). The surface morphologies and particle size distribution of the microspheres were investigated. The in-vitro