Neonatal alloimmune thrombocytopenia due to anti‐HPA 1a antibodies; the level of maternal antibodies predicts the severity of thrombocytopenia in the newborn

Eleven thousand one hundred pregnant women were genotyped for human platelet antigen HPA 1, and 198 HPA 1bb women were followed in the pregnancy with quantitative assay for anti‐HPA 1a antibodies. Antibodies were detected in 24 women, and nine children were born with severe thrombocytopenia (< 50...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2000-05, Vol.107 (5), p.691-694
Main Authors: Jægtvik, S., Husebekk, A., Aune, B., Øian, P., Dahl, L. B., Skogen, B.
Format: Article
Language:English
Subjects:
Antibodies - blood
Antigens, Human Platelet - blood
Antigens, Human Platelet - immunology
Biomarkers - blood
Female
Genotype
Hemorrhage - etiology
Humans
Infant, Newborn
Male
Pregnancy
Pregnancy Complications, Hematologic - immunology
Prenatal Diagnosis - methods
Thrombocytopenia - complications
Thrombocytopenia - diagnosis
Thrombocytopenia - genetics
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Summary:Eleven thousand one hundred pregnant women were genotyped for human platelet antigen HPA 1, and 198 HPA 1bb women were followed in the pregnancy with quantitative assay for anti‐HPA 1a antibodies. Antibodies were detected in 24 women, and nine children were born with severe thrombocytopenia (< 50×109/L). All mothers with high levels of antibodies were delivered of children with severe thrombocytopenia. None of the newborn infants had clinical signs of intra‐cranial haemorrhage. The level of maternal anti‐HPA 1a antibodies is predictive for fetal thrombocytopenia and may be used in decisions related to time and mode of delivery.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2000.tb13315.x