Birth of a healthy girl after ICSI with ejaculated spermatozoa from a man with non-mosaic Klinefelter's syndrome

Klinefelter's syndrome is a major contributor to male infertility. Recent reports of births after ICSI with especially testicular spermatozoa from infertile men with this syndrome are promising. The birth of a healthy girl after ICSI treatment with ejaculated spermatozoa from a man with non-mos...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2001-09, Vol.16 (9), p.1909-1911
Main Authors: CRÜGER, D, TOFT, B, AGERHOLM, I, FEDDER, J, HALD, F, BRUUN-PETERSEN, G
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Complex syndromes
Ejaculation
Female
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn - physiology
Klinefelter Syndrome - genetics
Klinefelter Syndrome - physiopathology
Labor, Obstetric
Male
Medical genetics
Medical sciences
Mosaicism
Pregnancy
Reference Values
Sperm Injections, Intracytoplasmic
Spermatozoa - physiology
Sterility. Assisted procreation
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Summary:Klinefelter's syndrome is a major contributor to male infertility. Recent reports of births after ICSI with especially testicular spermatozoa from infertile men with this syndrome are promising. The birth of a healthy girl after ICSI treatment with ejaculated spermatozoa from a man with non-mosaic Klinefelter's syndrome is reported. The non-mosaic karyotype was confirmed by chromosome analysis of both peripheral blood leukocytes and fibroblasts from a skin biopsy. In conclusion, in a very few cases, men with apparently non-mosaic Klinefelter's syndrome have ejaculated spermatozoa that can result in a birth of a healthy child following ICSI.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/16.9.1909