The 5,6- and 4,5-Benzo Derivatives of 1-Hydroxy-7-azabenzotriazole

Syntheses of the two benzo derivatives of HOAt are described. Conversion of the two isomers to the corresponding onium-style coupling reagents gave in one case a guandinium species 14 and in the other, presumably as a result of steric factors, a uronium species 15. The two systems are compared as to...

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Published in:Organic letters 2001-09, Vol.3 (18), p.2793-2795
Main Authors: Carpino, Louis A, Ferrer, Fernando J
Format: Article
Language:English
Subjects:
Aza Compounds - chemical synthesis
Aza Compounds - chemistry
Peptides - chemistry
Protein Isoforms
Triazoles - chemical synthesis
Triazoles - chemistry
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description Syntheses of the two benzo derivatives of HOAt are described. Conversion of the two isomers to the corresponding onium-style coupling reagents gave in one case a guandinium species 14 and in the other, presumably as a result of steric factors, a uronium species 15. The two systems are compared as to their effectiveness in peptide coupling processes.
doi_str_mv 10.1021/ol016063j
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Aza Compounds - chemical synthesis
Aza Compounds - chemistry
Peptides - chemistry
Protein Isoforms
Triazoles - chemical synthesis
Triazoles - chemistry
title The 5,6- and 4,5-Benzo Derivatives of 1-Hydroxy-7-azabenzotriazole
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