Synthesis and biological evaluation of l- and d-configurations of 2′,3′-dideoxy-4′-c-methyl-3′-oxacytidine analogues

Novel l- and d-configuration 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and l-ascorbic acid in eight steps and evaluated for biological activity. Novel l- and d-configurations of 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine an...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2001-09, Vol.11 (17), p.2301-2304
Main Authors: Liu, Mao-Chin, Luo, Mei-Zhen, Mozdziesz, Diane E., Lin, Tai-Shun, Dutschman, Ginger E., Gullen, Elizabeth A., Cheng, Yung-Chi, Sartorelli, Alan C.
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Biological and medical sciences
Cytidine - chemistry
Drug Screening Assays, Antitumor
General aspects
Leukemia L1210
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
Pharmacology. Drug treatments
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Summary:Novel l- and d-configuration 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and l-ascorbic acid in eight steps and evaluated for biological activity. Novel l- and d-configurations of 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized and evaluated for biological activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00441-3