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Synthesis and biological evaluation of l- and d-configurations of 2′,3′-dideoxy-4′-c-methyl-3′-oxacytidine analogues
Novel l- and d-configuration 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and l-ascorbic acid in eight steps and evaluated for biological activity. Novel l- and d-configurations of 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine an...
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| Published in: | Bioorganic & medicinal chemistry letters 2001-09, Vol.11 (17), p.2301-2304 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c390t-7d74da1a14d4e5addb392af97ee69f31d6489b27e5e355e866d6a67b049019373 |
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| cites | cdi_FETCH-LOGICAL-c390t-7d74da1a14d4e5addb392af97ee69f31d6489b27e5e355e866d6a67b049019373 |
| container_end_page | 2304 |
| container_issue | 17 |
| container_start_page | 2301 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 11 |
| creator | Liu, Mao-Chin Luo, Mei-Zhen Mozdziesz, Diane E. Lin, Tai-Shun Dutschman, Ginger E. Gullen, Elizabeth A. Cheng, Yung-Chi Sartorelli, Alan C. |
| description | Novel
l- and
d-configuration 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and
l-ascorbic acid in eight steps and evaluated for biological activity.
Novel
l- and
d-configurations of 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized and evaluated for biological activity. |
| doi_str_mv | 10.1016/S0960-894X(01)00441-3 |
| format | article |
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d-configuration 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and
l-ascorbic acid in eight steps and evaluated for biological activity.
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l- and
d-configurations of 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized and evaluated for biological activity.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(01)00441-3</identifier><identifier>PMID: 11527719</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antiviral agents ; Antiviral Agents - chemical synthesis ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Cytidine - chemistry ; Drug Screening Assays, Antitumor ; General aspects ; Leukemia L1210 ; Magnetic Resonance Spectroscopy ; Medical sciences ; Microbial Sensitivity Tests ; Molecular Structure ; Pharmacology. Drug treatments</subject><ispartof>Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2301-2304</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-7d74da1a14d4e5addb392af97ee69f31d6489b27e5e355e866d6a67b049019373</citedby><cites>FETCH-LOGICAL-c390t-7d74da1a14d4e5addb392af97ee69f31d6489b27e5e355e866d6a67b049019373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1115499$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11527719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Mao-Chin</creatorcontrib><creatorcontrib>Luo, Mei-Zhen</creatorcontrib><creatorcontrib>Mozdziesz, Diane E.</creatorcontrib><creatorcontrib>Lin, Tai-Shun</creatorcontrib><creatorcontrib>Dutschman, Ginger E.</creatorcontrib><creatorcontrib>Gullen, Elizabeth A.</creatorcontrib><creatorcontrib>Cheng, Yung-Chi</creatorcontrib><creatorcontrib>Sartorelli, Alan C.</creatorcontrib><title>Synthesis and biological evaluation of l- and d-configurations of 2′,3′-dideoxy-4′-c-methyl-3′-oxacytidine analogues</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Novel
l- and
d-configuration 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and
l-ascorbic acid in eight steps and evaluated for biological activity.
Novel
l- and
d-configurations of 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized and evaluated for biological activity.</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - chemical synthesis</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cytidine - chemistry</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General aspects</subject><subject>Leukemia L1210</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - chemical synthesis</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cytidine - chemistry</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General aspects</topic><topic>Leukemia L1210</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Pharmacology. 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l- and
d-configuration 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and
l-ascorbic acid in eight steps and evaluated for biological activity.
Novel
l- and
d-configurations of 2′,3′-dideoxy-4′-C-methyl-3′-oxacytidine and their 5-fluoro analogues have been synthesized and evaluated for biological activity.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11527719</pmid><doi>10.1016/S0960-894X(01)00441-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2301-2304 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71135391 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cytidine - chemistry Drug Screening Assays, Antitumor General aspects Leukemia L1210 Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments |
| title | Synthesis and biological evaluation of l- and d-configurations of 2′,3′-dideoxy-4′-c-methyl-3′-oxacytidine analogues |
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