Inhaled corticosteroids for maintenance treatment in childhood pulmonary sarcoidosis

• Published in: Acta Paediatrica 2001-08, Vol.90 (8), p.953-956
• Main Authors: Kiper, N, Anadol, D, Ouzçelik, U, Göçmen, A
• Format: Article
• Language: English
• Subjects: Administration, Inhalation; Administration, Oral; Adolescent; Anti-Inflammatory Agents - therapeutic use; Biological and medical sciences; Biopsy - methods; Child; Childhood; Female; Humans; inhaled corticosteroids; Male; Medical sciences; Pharmacology. Drug treatments; Prednisolone - therapeutic use; pulmonary sarcoidosis; Respiratory system; Retrospective Studies; Sarcoidosis, Pulmonary - diagnosis; Sarcoidosis, Pulmonary - drug therapy; Tomography Scanners, X-Ray Computed; Treatment Outcome
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.2001.tb02465.x

We present our experience with sequential oral and inhaled corticosteroid therapy in childhood pulmonary sarcoidosis. Fifteen children were followed‐up for a mean of 7y. Treatment consisted of oral prednisolone 2mg/kg/d on initial diagnosis. After remission was reached, alternate day therapy with 1 mg/kg was continued. The dose was tapered to a maintenance dose which controlled the activity of the disease. When patients were free of symptoms and had no clinical and laboratory findings, inhaled corticosteriod treatment was started. Relapse treatment consisted of cessation of inhaled corticosteroids and start of oral corticosteroids at a dosage of 2 mg/kg/d and then a tapered dose. Five patients were given oral corticosteroids only. Nine patients were given inhaled steroids after oral corticosteroid therapy had been discontinued. Clinical and radiological remissions were achieved in every patient. Conclusion: Sequential oral and inhaled corticosteroid therapy may be an alternative treatment regimen for sarcoidosis in children.