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Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis

To elucidate the relevance of metabotropic glutamate receptors (mGluRs) to the selective vulnerability of motor neurons in the spinal cord in patients with amyotrophic lateral sclerosis (ALS), we investigated the distribution of mRNAs coding mGluR1-5 in the normal human spinal cord. The mRNAs for mG...

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Published in:Journal of the neurological sciences 2001-08, Vol.189 (1), p.65-69
Main Authors: Tomiyama, Masahiko, Kimura, Tamaki, Maeda, Tetsuya, Tanaka, Hiroyasu, Furusawa, Kenichi, Kurahashi, Kozo, Matsunaga, Muneo
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container_title Journal of the neurological sciences
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description To elucidate the relevance of metabotropic glutamate receptors (mGluRs) to the selective vulnerability of motor neurons in the spinal cord in patients with amyotrophic lateral sclerosis (ALS), we investigated the distribution of mRNAs coding mGluR1-5 in the normal human spinal cord. The mRNAs for mGluR1, 4 and 5 were observed in the spinal gray matter, whereas mGluR2 mRNA was absent in the spinal cord and mGluR3 mRNA was displayed only on glial cells in the white matter. Signals for mGluR1 and mGluR5 were enriched in the dorsal horn, while mGluR4 mRNA was abundant in the ventral horn. Since agonists to group I mGluRs (mGluR 1 and 5) have been demonstrated to have neuroprotective effects on spinal motor neurons, less expression of mRNAs coding mGluR1 and mGluR5 in the ventral horn than in the dorsal horn may be implicated in the selective susceptibility of spinal motor neurons in ALS.
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subjects Aged
ALS
Biological and medical sciences
Cell Size
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Susceptibility
Excitotoxicity
Female
Gene Expression Profiling
Humans
In situ hybridization
Male
Medical sciences
mGluR
Middle Aged
Motor neuron death
Motor neuron disease
Motor Neuron Disease - metabolism
Motor Neurons - metabolism
Motor Neurons - ultrastructure
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Neurology
Protein Isoforms - biosynthesis
Protein Isoforms - genetics
Receptors, Metabotropic Glutamate - biosynthesis
Receptors, Metabotropic Glutamate - classification
Receptors, Metabotropic Glutamate - genetics
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Spinal Cord - cytology
Spinal Cord - metabolism
title Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis
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