Long-circulating liposomes of indomethacin in arthritic rats — a biodisposition study

To improve the targeting efficiency of liposomes of indomethacin to the arthritic joints, circulation half-life of the liposomes was increased by grafting amphipathic polyethylene glycol-2000 to the bilayer surface. A comparative biodistribution study was performed between the conventional liposomes...

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Bibliographic Details
Published in:Pharmaceutica acta Helvetiae 2000-04, Vol.74 (4), p.399-404
Main Authors: Srinath, P., Chary, M.G., Vyas, S.P., Diwan, P.V.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Arthritis
Biodistribution
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Drug Carriers
Drug targeting
General pharmacology
Indomethacin
Indomethacin - administration & dosage
Indomethacin - pharmacokinetics
Liposomes
Long-circulating liposomes
Male
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacokinetics
Pharmacology. Drug treatments
Phosphatidylcholines
Phosphatidylethanolamines
Rats
Rats, Wistar
Tissue Distribution
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Summary:To improve the targeting efficiency of liposomes of indomethacin to the arthritic joints, circulation half-life of the liposomes was increased by grafting amphipathic polyethylene glycol-2000 to the bilayer surface. A comparative biodistribution study was performed between the conventional liposomes (PC:CH:PE — 1:0.5:0.16) and long-circulating liposomes (PC:CH:PE-PEG — 1:0.5:0.16) in arthritic rats. Pharmocokinetics of the drug changed significantly when administered in liposomal form. Pharmacokinetic parameters of the drug such as AUC0-t (trapezoidal), clearance and t1/2 (elimination half-life) changed significantly (p
ISSN:0031-6865
DOI:10.1016/S0031-6865(00)00023-6