Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b)

We report here a case of acute monocytic leukemia (M5b subtype according to the French-American-British [FAB] classification) with chromosomal translocation t(11;20)(p15;q11.2). Fluorescence in situ hybridization analysis with a probe for the NUP98 gene, which is located at chromosome band 11p15, sh...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematology 2001-07, Vol.74 (1), p.53-57
Main Authors: KAKAZU, Naoki, SHINZATO, Isaku, OHKI, Misao, ABE, Tatsuo, ARAI, Yasuhito, GOTOH, Saori, MATSUSHITA, Akiko, ISHIKAWA, Takayuki, NAGAI, Kenichi, TAKAHASHI, Takayuki, OHNO, Tatsuji, TSUCHIYA, Takayuki
Format: Article
Language:English
Subjects:
Aclarubicin - administration & dosage
Anemia, Refractory, with Excess of Blasts - genetics
Anemia, Refractory, with Excess of Blasts - pathology
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Bone Marrow Transplantation
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 11 - ultrastructure
Chromosomes, Human, Pair 20 - genetics
Chromosomes, Human, Pair 20 - ultrastructure
Combined Modality Therapy
Cytarabine - administration & dosage
Cytarabine - analogs & derivatives
Disease Progression
Fatal Outcome
Female
Hematologic and hematopoietic diseases
Hemorrhage - etiology
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia
Leukemia, Monocytic, Acute - drug therapy
Leukemia, Monocytic, Acute - genetics
Leukemia, Monocytic, Acute - therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Mercaptopurine - administration & dosage
Middle Aged
Neoplasm Proteins - genetics
Nuclear Pore Complex Proteins - genetics
Prednisolone - administration & dosage
Sepsis - etiology
Translocation, Genetic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report here a case of acute monocytic leukemia (M5b subtype according to the French-American-British [FAB] classification) with chromosomal translocation t(11;20)(p15;q11.2). Fluorescence in situ hybridization analysis with a probe for the NUP98 gene, which is located at chromosome band 11p15, showed that the probe hybridized to both derivative chromosomes 11 and 20 as well as to the remaining normal chromosome 11, indicating that the NUP98 gene was split and involved in this translocation. This is the first report of t(11;20)(p15;q11.2) involving the NUP98 gene in overt leukemia.
ISSN:0925-5710
1865-3774
DOI:10.1007/BF02982549