MRI assessment of microvascular characteristics in experimental breast tumors using a new blood pool contrast agent (MS-325) with correlations to histopathology

A new contrast medium, MS‐325, was compared to albumin‐(Gd‐DTPA)30 in 18 chemically induced rat breast tumors based on quantitative estimates of microvascular permeability (KPS) and fractional plasma volume (fPV) using a two‐compartment bidirectional model. No significant correlation was found betwe...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2001-09, Vol.14 (3), p.237-242
Main Authors: Turetschek, Karl, Floyd, Eugenia, Helbich, Thomas, Roberts, Timothy P.L., Shames, David M., Wendland, Michael F., Carter, Wayne O., Brasch, Robert C.
Format: Article
Language:English
Subjects:
Animals
breast neoplasms
Capillary Permeability
contrast media
Contrast Media - metabolism
correlative studies
Disease Models, Animal
Female
Gadolinium
histologic tumor grade
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mammary Neoplasms, Experimental - blood supply
Mammary Neoplasms, Experimental - pathology
microvascular counts
Neoplasm Staging
Organometallic Compounds - metabolism
Rats
Rats, Sprague-Dawley
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Summary:A new contrast medium, MS‐325, was compared to albumin‐(Gd‐DTPA)30 in 18 chemically induced rat breast tumors based on quantitative estimates of microvascular permeability (KPS) and fractional plasma volume (fPV) using a two‐compartment bidirectional model. No significant correlation was found between MS‐325‐enhanced microvascular assays with either tumor grade or with microvascular counts (MVCs). In comparison, the correlation coefficient between KPS and histologic tumor grade using albumin‐(Gd‐DTPA)30 (r = .58) was statistically significant (P < .01). Also, using albumin‐(Gd‐DTPA)30, a significant correlation (r = .55, P < .05) was observed between the KPS and MVC, a biomarker of angiogenesis. Correlations between fPV and MVC were not statistically significant for either contrast medium. In conclusion, using MS‐325, no significant correlations between the MR‐estimated permeability values or plasma volumes were observed in experimental breast tumors with either the histologic tumor grade or MVC. This analysis confirms our previous determination that capillary permeability estimates, using a prototype large molecular contrast medium, albumin‐(Gd‐DTPA)30, correlate significantly with both histologic tumor grade and MVC. J. Magn. Reson. Imaging 2001;14:237–242. © 2001 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.1179