TCR usage in naive and committed alloreactive cells: implications for the understanding of TCR biases in transplantation

The direct pathway of allorecognition is involved in acute allograft rejection and is characterised by TCR-mediated recognition of the MHC framework; this is thought to occur in a peptide-dependent but not peptide-specific manner. In contrast, the indirect pathway is restricted to the recipient'...

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Bibliographic Details
Published in:Current Opinion in Immunology 2001-10, Vol.13 (5), p.566-571
Main Authors: Guillet, Marina, Sebille, Fabien, Soulillou, Jean-Paul
Format: Article
Language:English
Subjects:
allorecognition
alterations
Animals
Humans
Interphase - immunology
Isoantigens - immunology
Receptors, Antigen, T-Cell - immunology
Receptors, Antigen, T-Cell - metabolism
Receptors, Antigen, T-Cell, alpha-beta - immunology
Receptors, Antigen, T-Cell, alpha-beta - metabolism
TCR
transplantation
Transplantation Immunology - immunology
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Summary:The direct pathway of allorecognition is involved in acute allograft rejection and is characterised by TCR-mediated recognition of the MHC framework; this is thought to occur in a peptide-dependent but not peptide-specific manner. In contrast, the indirect pathway is restricted to the recipient's own MHC molecules and prevails in chronic rejection. In this pathway, the peptide has a major influence on the TCR recognition and selects alloreactive T cells with altered TCR Vβ usage. However, qualitative analysis of Vβ usage alone might limit our understanding of alloreactivity. The advantages of a combined quantitative assessment of Vβ mRNA usage are discussed.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(00)00260-0