Genetic Diversity of a Population of Schistosoma Haematobium Derived from Schoolchildren in East Central Zimbabwe

To characterize the extent of genetic diversity of Schistosoma haematobium within and among its definitive host (intra- and interhost parasite diversity), 133 individual isolates from 25 infected schoolchildren were compared using randomly amplified polymorphic DNA markers. With 4 primers, 53 unambi...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of parasitology 2001-08, Vol.87 (4), p.762-769
Main Authors: Brouwer, Kimberly C, Ndhlovu, Patricia, Munatsi, Anderson, Shiff, Clive J
Format: Article
Language:English
Subjects:
Adolescent
Alleles
Animals
Biological and medical sciences
Child
DNA
DNA, Helminth - genetics
Fundamental and applied biological sciences. Psychology
Genetic diversity
Genetic loci
Genetic Variation
Genetics of eukaryotes. Biological and molecular evolution
GENETICS-EVOLUTION
Genotypes
Human genetics
Humans
Infections
Invertebrata
Molecular Epidemiology
Parasite hosts
Parasites
Population genetics
Population genetics, reproduction patterns
Schistosoma haematobium - classification
Schistosoma haematobium - genetics
Schistosomiasis haematobia - epidemiology
Urine - parasitology
Zimbabwe - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To characterize the extent of genetic diversity of Schistosoma haematobium within and among its definitive host (intra- and interhost parasite diversity), 133 individual isolates from 25 infected schoolchildren were compared using randomly amplified polymorphic DNA markers. With 4 primers, 53 unambiguous loci were identified, and of these, 22 were polymorphic. Mean heterozygosity in the population was 0.116 ± 0.043. Analysis of molecular variance showed the majority of variance occurred within, rather than between, hosts. Frequencies of certain alleles segregated the parasite population into 13 distinct clusters of associated genotypes, with 4 of these first appearing 10 mo after the initial survey. Considering the level of diversity within this limited geographical area and the possibility of rapid turnover of genotypes, parasite variance may impact acquired immunity and clinical outcome of the infection.
ISSN:0022-3395
1937-2345
DOI:10.1645/0022-3395(2001)087[0762:GDOAPO]2.0.CO;2