HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum

Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase...

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Bibliographic Details
Published in:Archives of pharmacal research 2001-08, Vol.24 (4), p.286-291
Main Authors: Kim, H J, Woo, E R, Shin, C G, Hwang, D J, Park, H, Lee, Y S
Format: Article
Language:English
Subjects:
Disaccharides - pharmacology
Guaiacol - analogs & derivatives
Guaiacol - pharmacology
HIV Integrase Inhibitors - pharmacology
HIV-1 - enzymology
Humans
Magnetic Resonance Spectroscopy
Oligonucleotides - pharmacology
Plant Extracts - analysis
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
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Summary:Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 microM, respectively.
ISSN:0253-6269
DOI:10.1007/BF02975093