Anoikis mechanisms

Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell–matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals contro...

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Bibliographic Details
Published in:Current Opinion in Cell Biology 2001-10, Vol.13 (5), p.555-562
Main Authors: Frisch, Steven M, Screaton, Robert A
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Anoikis
apoptosis
Carrier Proteins - metabolism
cell adhesion
Cytoskeleton - physiology
Erk
FAK
Fas-Associated Death Domain Protein
Growth Substances - physiology
Humans
integrin
Integrins - physiology
Jun N-terminal kinase
MAP Kinase Signaling System
Models, Biological
Neoplasms - pathology
Phosphatidylinositol 3-Kinases - physiology
PI3K
protein kinase
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins - physiology
Proto-Oncogene Proteins c-akt
RAF
Signal Transduction
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Summary:Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell–matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(00)00251-9