Distribution of tyrosine aminotransferase activity in mink ( Mustela vison)

The distribution of the enzyme tyrosine aminotransferase in tissues of mink, Mustela vison, was investigated. High levels of enzymatic activity were detected only in liver, documenting the hepatic-specific nature of this enzyme in this species. Further studies disclosed that tyrosine aminotransferas...

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Bibliographic Details
Published in:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2001-09, Vol.130 (2), p.251-256
Main Authors: Prieur, David J, Gorham, John R, Wood, Rinda K
Format: Article
Language:English
Subjects:
Animals
Enzyme
Enzyme Stability
Fasting
Gene Dosage
Genetic disease
Kidney - enzymology
Liver
Liver - enzymology
Liver - physiology
Metabolic disease
Mink
Mink - metabolism
Sonication
Spleen - enzymology
Telencephalon - enzymology
Temperature
Tissue Distribution
Tyrosine
Tyrosine aminotransferase
Tyrosine Transaminase - metabolism
Tyrosinemia
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Summary:The distribution of the enzyme tyrosine aminotransferase in tissues of mink, Mustela vison, was investigated. High levels of enzymatic activity were detected only in liver, documenting the hepatic-specific nature of this enzyme in this species. Further studies disclosed that tyrosine aminotransferase is not absent from non-hepatic tissues because of the lack of the use of a stabilized buffer, sensitivity to temperature, or due to the presence of an inhibitor. Collectively, these results suggest that the enzymatic assay of tyrosine aminotransferase will be unlikely to be an efficacious approach for identifying mink that are heterozygous for the autosomal recessive deficiency of this enzyme that is common in dark mink.
ISSN:1096-4959
1879-1107
DOI:10.1016/S1096-4959(01)00428-6