The role of cytotoxicity in lymphocyte homeostasis

Several human inherited immune disorders lead to the same fatal lymphoproliferative syndrome, called the hemophagocytic syndrome. Through defective perforin expression or transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in the regulation of the immune resp...

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Bibliographic Details
Published in:Current Opinion in Immunology 2001-10, Vol.13 (5), p.549-554
Main Authors: de Saint Basile, Geneviève, Fischer, Alain
Format: Article
Language:English
Subjects:
Animals
Cytotoxicity, Immunologic - immunology
hemophagocytic syndrome
Homeostasis - immunology
human disorders
Humans
immune homeostasis
Lymphocyte Subsets - immunology
LYST
perforin
Rab27a
secretory cytotoxic pathway
viral infection
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Summary:Several human inherited immune disorders lead to the same fatal lymphoproliferative syndrome, called the hemophagocytic syndrome. Through defective perforin expression or transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in the regulation of the immune response and in lymphocyte homeostasis. In addition, new effectors of this secretory pathway have been identified.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(00)00257-0