Polymorphism in the promoter region of the gene encoding human allograft inflammatory factor-1

Summary We have identified a new single nucleotide polymorphism within the promoter region of the human allograft inflammatory factor (AIF‐1) gene. The polymorphism, defined by Genbank accession number AF097515, was characterized as a C/T single base pair substitution at position −932. The T allele...

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Bibliographic Details
Published in:European journal of immunogenetics 2001-08, Vol.28 (4), p.449-450
Main Authors: Turner, D. M., Pravica, V., Sinnott, P. J., Hutchinson, I. V.
Format: Article
Language:English
Subjects:
Alleles
allograft inflammatory factor 1
Base Sequence
Calcium-Binding Proteins - genetics
DNA-Binding Proteins
Gene Frequency - genetics
histocompatibility locus HLA
HLA-B7 Antigen - genetics
HLA-DR Antigens - genetics
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
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Summary:Summary We have identified a new single nucleotide polymorphism within the promoter region of the human allograft inflammatory factor (AIF‐1) gene. The polymorphism, defined by Genbank accession number AF097515, was characterized as a C/T single base pair substitution at position −932. The T allele is associated with both HLA‐DR2 and HLA‐B7. Also, this allele creates the consensus binding site for the E‐box that has high affinity for the basic helix‐loop‐helix (bHLH) family of transcription factors.
ISSN:0960-7420
1365-2370
DOI:10.1046/j.1365-2370.2001.00241.x