Clinical features of symptomatic Rathke's cleft cyst

To investigate the clinical features of Rathke's cleft cysts (RCCs), we retrospectively analyzed 15 cases with histologically confirmed RCCs. All patients underwent formal testing of visual field, endocrinological evaluation and magnetic resonance imagings. As overall presenting symptoms, endoc...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2001-07, Vol.103 (2), p.96-100
Main Authors: Isono, Mitsuo, Kamida, Tohru, Kobayashi, Hidenori, Shimomura, Tsuyoshi, Matsuyama, Junko
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Central Nervous System Cysts - diagnosis
Central Nervous System Cysts - surgery
Diabetes insipidus
Diabetes Insipidus - etiology
Diagnosis, Differential
Disease Progression
Dwarfism
Dwarfism, Pituitary - etiology
Female
Headache
Humans
Hyperprolactinemia
Hyperprolactinemia - etiology
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Neurology
Pituitary Gland - pathology
Rathke's cleft cyst
Retrospective Studies
Tumors of the nervous system. Phacomatoses
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Summary:To investigate the clinical features of Rathke's cleft cysts (RCCs), we retrospectively analyzed 15 cases with histologically confirmed RCCs. All patients underwent formal testing of visual field, endocrinological evaluation and magnetic resonance imagings. As overall presenting symptoms, endocrine disturbance was the most common symptoms, followed by visual disturbance and headache. Among the endocrine disturbances based on adenohypophysial dysfunction, hyperprolactinemia was most common. Considering the size of RCCs, RCCs could induce hyperprolactinemia only when the cysts became large enough to compress the infundibular system. Our series showed relative high incidence of pituitary dwarfism and diabetes insipidus (DI). These facts indicated that RCCs could evoke hyposecretion of growth hormone in young patients and DI in aged patients by direct compression of the pituitary gland in the early stage of progression. All cases who had headache had no other symptoms. We could not prove the evidence that RCCs could induce headaches in these cases. This might be suggested that headache could not be a sole symptom in cases of RCCs.
ISSN:0303-8467
1872-6968
DOI:10.1016/S0303-8467(01)00121-4