Integrin tyrosine phosphorylation in platelet signaling

The β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the β-integrin cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective aggregates and poorly retracted clots...

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Bibliographic Details
Published in:Current Opinion in Cell Biology 2001-10, Vol.13 (5), p.546-554
Main Authors: Phillips, David R, Prasad, KS Srinivasa, Manganello, Jeanne, Bao, Ming, Nannizzi-Alaimo, Lisa
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
aIIbb3
Amino Acid Sequence
Animals
Antigens, CD - chemistry
Antigens, CD - metabolism
Blood Platelets - physiology
GPIIb-IIIa
Integrin beta3
Mice
Molecular Sequence Data
Myosins - metabolism
Phosphorylation
Phosphotyrosine - metabolism
Platelet Adhesiveness
Platelet Aggregation
Platelet Glycoprotein GPIIb-IIIa Complex - chemistry
Platelet Glycoprotein GPIIb-IIIa Complex - metabolism
Platelet Membrane Glycoproteins - chemistry
Platelet Membrane Glycoproteins - metabolism
platelets
Proteins - metabolism
Shc Signaling Adaptor Proteins
Signal Transduction
signaling
Src Homology 2 Domain-Containing, Transforming Protein 1
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Summary:The β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the β-integrin cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of β3-integrin signals.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(00)00250-7