A potential role for arginase in recurrent infections and hypertrophy of tonsillar and adenoidal tissue

Since arginase has been found to be an arginine-depleting and nitric oxide synthase-regulating enzyme, the present study was devised to examine hypertrophied and infected tonsil and adenoid arginase activity in relation to a metabolic arginase-nitric oxide pathway and its association with disease pr...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2000, Vol.257 (3), p.158-160
Main Authors: ELGÜN, S, GÜNEY, K, TUNCER, M, GÖKHUN, I. H
Format: Article
Language:English
Subjects:
Adenoids - pathology
Adolescent
Arginase - metabolism
Arginine - metabolism
Biological and medical sciences
Child
Female
Humans
Hypertrophy
Male
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
Palatine Tonsil - pathology
Recurrence
Tonsillitis - pathology
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Since arginase has been found to be an arginine-depleting and nitric oxide synthase-regulating enzyme, the present study was devised to examine hypertrophied and infected tonsil and adenoid arginase activity in relation to a metabolic arginase-nitric oxide pathway and its association with disease processes. Tissues were taken from 32 children undergoing adenotonsillectomy. There was a statistically significant difference between the two tissue enzyme activities, with tonsillar arginase activity being higher than the corresponding adenoidal tissue (P < 0.005). This suggests a potential role for tissue arginase activity as an outcome module and a contributing factor in chronic recurrent infection and hypertrophy of tonsillar and adenoidal tissues.
ISSN:0937-4477
1434-4726
DOI:10.1007/s004050050214