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Synthesis, DNA-binding, and Antiviral Activity of Certain Pyrazolo[3,4-d]pyrimidine Derivatives

Some new pyrazolo[3,4‐d]pyrimidine derivatives have been prepared and tested for their antiviral and DNA‐binding activities. Compounds 4, 5, and 6 showed high binding affinity to DNA at concentrations of 19, 27, and 28 μg/ml, respectively. On the other hand, compounds 6 and 10 reduced the number of...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2000-04, Vol.333 (4), p.99-103
Main Authors: El-Bendary, E. R., Badria, F. A.
Format: Article
Language:English
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Summary:Some new pyrazolo[3,4‐d]pyrimidine derivatives have been prepared and tested for their antiviral and DNA‐binding activities. Compounds 4, 5, and 6 showed high binding affinity to DNA at concentrations of 19, 27, and 28 μg/ml, respectively. On the other hand, compounds 6 and 10 reduced the number of viral plaques of Herpes simplex type‐1 (HSV‐1) by 66 and 41%, respectively. The detailed synthesis and spectroscopic and biological data are reported.
ISSN:0365-6233
1521-4184
DOI:10.1002/(SICI)1521-4184(20004)333:4<99::AID-ARDP99>3.0.CO;2-O