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Synthesis, DNA-binding, and Antiviral Activity of Certain Pyrazolo[3,4-d]pyrimidine Derivatives
Some new pyrazolo[3,4‐d]pyrimidine derivatives have been prepared and tested for their antiviral and DNA‐binding activities. Compounds 4, 5, and 6 showed high binding affinity to DNA at concentrations of 19, 27, and 28 μg/ml, respectively. On the other hand, compounds 6 and 10 reduced the number of...
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Published in: | Archiv der Pharmazie (Weinheim) 2000-04, Vol.333 (4), p.99-103 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Some new pyrazolo[3,4‐d]pyrimidine derivatives have been prepared and tested for their antiviral and DNA‐binding activities. Compounds 4, 5, and 6 showed high binding affinity to DNA at concentrations of 19, 27, and 28 μg/ml, respectively. On the other hand, compounds 6 and 10 reduced the number of viral plaques of Herpes simplex type‐1 (HSV‐1) by 66 and 41%, respectively. The detailed synthesis and spectroscopic and biological data are reported. |
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ISSN: | 0365-6233 1521-4184 |
DOI: | 10.1002/(SICI)1521-4184(20004)333:4<99::AID-ARDP99>3.0.CO;2-O |