Effects of amitriptyline on diurnal variations of oxidation-reduction enzyme activities in rat lymphocytes during experimental desynchronosis

We studied the effects of amitriptyline on diurnal variations of oxidative-reduction enzyme activities (succinate dehydrogenase, lactate dehydrogenase, and NADPH diaphorase) in rat peripheral blood lymphocytes during experimental desynchronosis. Desynchronosis was induced by constant light exposure...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2001-05, Vol.131 (5), p.490-492
Main Authors: Litvinenko, G I, Shurlygina, A V, Trufakin, V A
Format: Article
Language:English
Subjects:
Amitriptyline - pharmacology
Animals
Circadian Rhythm
Cortical Synchronization
L-Lactate Dehydrogenase - blood
Light
Lymphocytes - enzymology
Male
NADPH Dehydrogenase - blood
Oxidation-Reduction
Rats
Rats, Wistar
Succinate Dehydrogenase - blood
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effects of amitriptyline on diurnal variations of oxidative-reduction enzyme activities (succinate dehydrogenase, lactate dehydrogenase, and NADPH diaphorase) in rat peripheral blood lymphocytes during experimental desynchronosis. Desynchronosis was induced by constant light exposure for 14 days and manifested in a morning shift of maximum lactate dehydrogenase activity and elevated morning NADPH diaphorase activity. Amitriptyline normalized morning lactate dehydrogenase activity and diurnal variations in NADPH diaphorase activity.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1017996503730