Calpain3 expression during human cardiogenesis

Transcripts of calpain3, the gene involved in limb girdle muscular dystrophy type 2A, appear in organs other than the skeletal muscle during human development, the first of which being the early embryonic heart. We examined more precisely the spatio-temporal transcription pattern of calpain3 during...

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Bibliographic Details
Published in:Neuromuscular disorders : NMD 2000-06, Vol.10 (4), p.251-256
Main Authors: Fougerousse, Françoise, Anderson, Louise V.B., Delezoide, Anne-Lise, Suel, Laurence, Durand, Muriel, Beckmann, Jacques S.
Format: Article
Language:English
Subjects:
Age Factors
Calpain - genetics
Calpain3
Cardiogenesis
Connectin
Embryo, Mammalian
Gene Expression Regulation, Developmental
Heart - embryology
Human development
Humans
Isoenzymes
Limb girdle muscular dystrophy
Muscle Fibers, Skeletal - metabolism
Muscle Proteins - genetics
Myocardium - metabolism
Peptide Fragments - genetics
Protein Kinases - genetics
RNA, Messenger - metabolism
Titin
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Summary:Transcripts of calpain3, the gene involved in limb girdle muscular dystrophy type 2A, appear in organs other than the skeletal muscle during human development, the first of which being the early embryonic heart. We examined more precisely the spatio-temporal transcription pattern of calpain3 during human cardiogenesis and the appearance of its protein in fetal tissues, and correlated it to titin expression. Different events of the heart's maturation can be recognized: (i) the presence of titin RNA or protein constitute very precocious developmental cardiac markers appearing before the fusion of the two lateral endocardial tubes; (ii) the disappearance of calpain3 RNA from the ventricular compartment later in the embryonic heart. Finally, although calpain3 transcripts are present in the heart, the corresponding protein is not detected elsewhere than in skeletal muscle.
ISSN:0960-8966
1873-2364
DOI:10.1016/S0960-8966(99)00107-8