Cell behaviour of Drosophila fat cadherin mutations in wing development

We have studied several cell behaviour parameters of mutant alleles of fat (ft) in Drosophila imaginal wing disc development. Mutant imaginal discs continue growing in larvae delayed in pupariation and can reach sizes of several times those of wild-type. Their growth is, however, basically allometri...

Full description

Saved in:
Bibliographic Details
Published in:Mechanisms of development 2000-06, Vol.94 (1-2), p.95-109
Main Authors: Garoia, F, Guerra, D, Pezzoli, M C, López-Varea, A, Cavicchi, S, García-Bellido, A
Format: Article
Language:English
Subjects:
Alleles
Animals
Cadherins - genetics
Cadherins - metabolism
Cell Differentiation - genetics
Cell Division - genetics
Drosophila - genetics
Drosophila - growth & development
ErbB Receptors - metabolism
Gene Expression Regulation, Developmental
Hyperplasia
Larva
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mosaicism
Mutation
Regeneration
Signal Transduction
Wings, Animal - growth & development
Wings, Animal - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have studied several cell behaviour parameters of mutant alleles of fat (ft) in Drosophila imaginal wing disc development. Mutant imaginal discs continue growing in larvae delayed in pupariation and can reach sizes of several times those of wild-type. Their growth is, however, basically allometric. Homozygous ft cells grow faster than their twin cells in clones and generate larger territories, albeit delimited by normal clonal restrictions. Moreover, ft cells in clones tend to grow towards wing proximal regions. These behaviours can be related with failures in cell adhesiveness and cell recognition. Double mutant combinations with alleles of other genes, e.g. of the Epidermal growth factor receptor (DER) pathway, modify ft clonal phenotypes, indicating that adhesiveness is modulated by intercellular signalling. Mutant ft cells show, in addition, smaller cell sizes during proliferation and abnormal cuticular differentiation, which reflect cell membrane and cytoskeleton anomalies, which are not modulated by the DER pathway.
ISSN:0925-4773
DOI:10.1016/S0925-4773(00)00306-3