Hyaluronan Enters Keratinocytes by a Novel Endocytic Route for Catabolism

Hyaluronan synthesized in the epidermis has an exceptionally short half-life, indicative of its catabolism by epidermal keratinocytes. An intracellular pool of endogenously synthesized hyaluronan, from 1 to 20 fg/cell, inversely related to cell density, was observed in cultured rat epidermal keratin...

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Bibliographic Details
Published in:The Journal of biological chemistry 2001-09, Vol.276 (37), p.35111-35122
Main Authors: Tammi, Raija, Rilla, Kirsi, Pienimäki, Juha-Pekka, MacCallum, Donald K., Hogg, Michael, Luukkonen, Merja, Hascall, Vincent C., Tammi, Markku
Format: Article
Language:English
Subjects:
Animals
Caveolae - metabolism
Cells, Cultured
Cytoplasm - metabolism
Endocytosis
Golgi Apparatus - metabolism
Hyaluronan Receptors - analysis
Hyaluronan Receptors - physiology
Hyaluronic Acid - analysis
Hyaluronic Acid - metabolism
Keratinocytes - metabolism
Lysosomes - metabolism
Molecular Weight
Rats
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Summary:Hyaluronan synthesized in the epidermis has an exceptionally short half-life, indicative of its catabolism by epidermal keratinocytes. An intracellular pool of endogenously synthesized hyaluronan, from 1 to 20 fg/cell, inversely related to cell density, was observed in cultured rat epidermal keratinocytes. More than 80% of the intracellular hyaluronan was small (
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M103481200