Effects of REM sleep deprivation on cholinergic receptor sensitivity and passive avoidance behavior in clomipramine model of depression

This study investigated the effects of REM (rapid eye movement) sleep deprivation (RSD) on the activity of central cholinergic receptors and passive avoidance retention in rats treated neonatally with clomipramine. Male rat pups treated with clomipramine (15 mg/kg, s.c.) twice daily from postnatal d...

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Bibliographic Details
Published in:Brain research 2000-06, Vol.867 (1), p.243-245
Main Authors: Prathiba, J, Kumar, K.B, Karanth, K.S
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Animals, Newborn
Avoidance Learning - drug effects
Avoidance Learning - physiology
Biological and medical sciences
Cholinergic sensitivity
clomipramine
Clomipramine - pharmacology
Depression
Depression - physiopathology
Male
Medical sciences
Mood disorders
Motor Activity - drug effects
Motor Activity - physiology
Muscarinic Agonists - pharmacology
Neonatal clomipramine
Oxotremorine
Oxotremorine - pharmacology
Passive avoidance
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rats
Rats, Wistar
Receptors, Cholinergic - physiology
REM sleep deprivation
Serotonin Uptake Inhibitors - pharmacology
Sleep Deprivation - physiopathology
Sleep, REM - physiology
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Summary:This study investigated the effects of REM (rapid eye movement) sleep deprivation (RSD) on the activity of central cholinergic receptors and passive avoidance retention in rats treated neonatally with clomipramine. Male rat pups treated with clomipramine (15 mg/kg, s.c.) twice daily from postnatal day 5 to 21 were subjected to RSD procedure at three months of age, for 4 days consecutively. In the post-RSD phase, RSD-control rats showed a significantly enhanced cholinomimetic-induced hypothermia and an improved retention in passive avoidance task. However, these measures were not significantly different in RSD-experimental group as compared to rats treated neonatally with saline. These results suggest that RSD reverses the sensitivity of central cholinergic receptors in rats given clomipramine neonatally, and this mechanism may be involved in mediating the antidepressant effects of RSD treatment in clomipramine model of depression.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(00)02248-4