Chlamydia pneumoniae in Atherosclerotic and Nonatherosclerotic Tissue

The positivity rate and localization of Chlamydia pneumoniae were investigated in atherosclerotic and nonatherosclerotic tissues by immunohistochemistry, polymerase chain reaction, and cell culture. In total, 67 atheromatous plaques from Japanese symptomatic patients and 110 nonatherosclerotic tissu...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-06, Vol.181 (Supplement-3), p.S441-S443
Main Authors: Ouchi, Kazunobu, Fujii, Banyo, Kudo, Sachiko, Shirai, Mutsunori, Yamashita, Katsuhiro, Gondo, Toshikazu, Ishihara, Tokuhiro, Ito, Haruhide, Nakazawa, Teruko
Format: Article
Language:English
Subjects:
Adult
Antibodies, Bacterial - blood
Arteries - microbiology
Arteriosclerosis - microbiology
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Atherosclerotic plaque
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Carotid Arteries - microbiology
Child, Preschool
Chlamydia Infections - microbiology
Chlamydia pneumoniae
Chlamydophila pneumoniae
Chlamydophila pneumoniae - genetics
Chlamydophila pneumoniae - growth & development
Chlamydophila pneumoniae - immunology
Chlamydophila pneumoniae - isolation & purification
Coronary Artery Disease - microbiology
Coronary Vessels - microbiology
Detection, Isolation, and Susceptibility Testing of Chlamydia pneumoniae
Endothelial cells
Endothelium, Vascular - microbiology
Humans
Immunohistochemistry
Infant
Infant, Newborn
Infections
Japan
Macrophages
Macrophages - microbiology
Medical sciences
Muscle, Smooth, Vascular - microbiology
Polymerase Chain Reaction
Predisposing factors
Smooth muscle myocytes
Specimens
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Description
Summary:The positivity rate and localization of Chlamydia pneumoniae were investigated in atherosclerotic and nonatherosclerotic tissues by immunohistochemistry, polymerase chain reaction, and cell culture. In total, 67 atheromatous plaques from Japanese symptomatic patients and 110 nonatherosclerotic tissues and organs were evaluated. Of these, 62% of atherosclerotic plaques from symptomatic patients were infected with C. pneumoniae compared with just 2% of nonatherosclerotic tissues. Immunohistochemically stained C. pneumoniae were found most often in smooth muscle cells, less often in macrophages, and in a few endothelial cells.
ISSN:0022-1899
1537-6613
DOI:10.1086/315617