Molecular mechanisms and regulation of opioid receptor signaling

Cloning of multiple opioid receptors has presented opportunities to investigate the mechanisms of multiple opioid receptor signaling and the regulation of these signals. The subsequent identification of receptor gene structures has also provided opportunities to study the regulation of receptor gene...

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Bibliographic Details
Published in:Annual review of pharmacology and toxicology 2000-01, Vol.40 (1), p.389-430
Main Authors: Law, P Y, Wong, Y H, Loh, H H
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
Animals
Calcium - metabolism
Calcium Channels - physiology
Gene Expression Regulation
Humans
MAP Kinase Signaling System
Phosphorylation
Potassium Channels - physiology
Receptors, Opioid - drug effects
Receptors, Opioid - genetics
Receptors, Opioid - physiology
Type C Phospholipases - metabolism
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Summary:Cloning of multiple opioid receptors has presented opportunities to investigate the mechanisms of multiple opioid receptor signaling and the regulation of these signals. The subsequent identification of receptor gene structures has also provided opportunities to study the regulation of receptor gene expression and to manipulate the concentration of the gene products in vivo. Thus, in the current review, we examine recent advances in the delineation basis for the multiple opioid receptor signaling, and their regulation at multiple levels. We discuss the use of receptor knockout animals to investigate the function and the pharmacology of these multiple opioid receptors. The reasons and basis for the multiple opioid receptor are addressed.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev.pharmtox.40.1.389