Multiple Myeloma Showing Increased Accumulation of Tc-99m Hexamethylpropylene Amine Oxime on Brain SPECT

The authors report a case of multiple myeloma with increased accumulation of Tc-99m hexamethylpropylene amine oxime (HMPAO) on brain SPECT. Tc-99m HMPAO is a lipophilic compound that freely passes through the intact blood-brain barrier and cell membrane and is rapidly converted to a hydrophilic form...

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Bibliographic Details
Published in:Clinical nuclear medicine 2000-06, Vol.25 (6), p.495-496
Main Authors: TAKESHITA, TORU, KAMINAGA, TATSURO, KIKUCHI, YOSHIRO, FURUI, SHIGERU
Format: Article
Language:English
Subjects:
Blood-Brain Barrier
Brain Neoplasms - blood supply
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Female
Humans
Middle Aged
Multiple Myeloma - diagnostic imaging
Multiple Myeloma - pathology
Radiopharmaceuticals
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
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Summary:The authors report a case of multiple myeloma with increased accumulation of Tc-99m hexamethylpropylene amine oxime (HMPAO) on brain SPECT. Tc-99m HMPAO is a lipophilic compound that freely passes through the intact blood-brain barrier and cell membrane and is rapidly converted to a hydrophilic form by glutathione and then retained in the neuron for several hours. In general, Tc-99m HMPAO shows decreased accumulation in brain tumors. However, some reports of increased accumulation in brain tumors, such as meningioma, glioblastoma multiforme, high-grade astrocytoma, pituitary adenoma, and multiple myeloma, have been published. The Tc-99m HMPAO uptake in these tumors has been attributed to tumor blood flow or glutathione contents within the tumor. With regard to uptake to Tc-99m HMPAO in multiple myeloma, the tumor size is considered to be an additional factor.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-200006000-00030