Tc-99m Sestamibi and In-111 DTPA Octreotide Uptake in Breast Carcinoma With Neurendocrine Differentiation

Some breast tumors are classified as primary neuroendocrine carcinomas because of argyrophilia and positivity for neuroendocrine markers (chromogranins A and B and neuron-specific enolase), regardless of their cellular rest and cord structures. Tc-99m sestamibi has been widely used to identify epith...

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Bibliographic Details
Published in:Clinical nuclear medicine 2000-06, Vol.25 (6), p.482-483
Main Authors: RUBINI, GIUSEPPE, D’EREDITÀ, GIOVANNI
Format: Article
Language:English
Subjects:
Aged
Breast Neoplasms - diagnostic imaging
Carcinoma - diagnostic imaging
Carcinoma, Neuroendocrine - diagnostic imaging
Diagnosis, Differential
Female
Humans
Indium Radioisotopes
Octreotide - analogs & derivatives
Pentetic Acid - analogs & derivatives
Radionuclide Imaging
Radiopharmaceuticals
Technetium Tc 99m Sestamibi
Terbium
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Summary:Some breast tumors are classified as primary neuroendocrine carcinomas because of argyrophilia and positivity for neuroendocrine markers (chromogranins A and B and neuron-specific enolase), regardless of their cellular rest and cord structures. Tc-99m sestamibi has been widely used to identify epithelial breast carcinoma and lymph node metastases, whereas In-111 DTPA-octreotide has been used to identify primary and secondary neuroendocrine neoplasms specifically. The use of In-111 DTPA-octreotide and Tc-99m sestamibi scintigraphy in a woman with neuroendocrine differentiated cancer of the left breast is reported. Uptake of these radiopharmaceuticals only in the breast tumor permitted identification of a primary breast carcinoma, whereas absence of In-111 DTPA-octreotide uptake in other sites helped to exclude the presence of other neuroendocrine neoplasms in other organs.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-200006000-00023