Teicoplanin therapy for Staphylococcus aureus septicaemia: relationship between pre-dose serum concentrations and outcome

Logistic regression analysis was performed on data drawn from a clinical trials database for Staphylococcus aureus septicaemia treated with teicoplanin. Variables analysed were age, body weight, mean pre-dose and post-dose serum teicoplanin concentrations, mean dose (mg or mg/kg body weight) and com...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2000-06, Vol.45 (6), p.835-841
Main Authors: Harding, I., MacGowan, A. P., White, L. O., Darley, E. S. R., Reed, V.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Algorithms
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Body Weight
Humans
Logistic Models
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Pharmacology. Drug treatments
Sepsis - drug therapy
Sepsis - epidemiology
Staphylococcal Infections - drug therapy
Staphylococcal Infections - epidemiology
Staphylococcus aureus
teicoplanin
Teicoplanin - administration & dosage
Teicoplanin - blood
Teicoplanin - therapeutic use
Treatment Outcome
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Summary:Logistic regression analysis was performed on data drawn from a clinical trials database for Staphylococcus aureus septicaemia treated with teicoplanin. Variables analysed were age, body weight, mean pre-dose and post-dose serum teicoplanin concentrations, mean dose (mg or mg/kg body weight) and combination versus monotherapy. Only two variables correlated with clinical outcome at a significance level better than 0.05: age (P = 0.012) and mean pre-dose serum concentration (P = 0.010). The probability of successful treatment declined with age and increased with mean pre-dose serum concentration.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/45.6.835