Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat

• Published in: Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2001-08, Vol.65 (2), p.91-97
• Main Authors: Abeywardena, M.Y., Head, R.J.
• Format: Article
• Language: English
• Subjects: Acetylcholine - antagonists & inhibitors; Acetylcholine - pharmacology; alpha-Tocopherol - pharmacology; Animals; Antioxidants - metabolism; Antioxidants - pharmacology; Aorta - metabolism; Biological and medical sciences; Cardiovascular Agents - pharmacology; Diet; Dose-Response Relationship, Drug; Endothelium, Vascular - metabolism; Fatty Acids, Unsaturated - metabolism; Feeding. Feeding behavior; Flavonoids - pharmacology; Fundamental and applied biological sciences. Psychology; Hydrazines - pharmacology; Hypertension - prevention & control; Indomethacin - pharmacology; Kaempferols; Lipid Metabolism; Nitric Oxide - metabolism; Phthalic Acids - pharmacology; Plant Oils - therapeutic use; Platelet Aggregation Inhibitors - pharmacology; Quercetin - analogs & derivatives; Quercetin - pharmacology; Rats; Rats, Inbred SHR; Rutin - pharmacology; Umbelliferones - pharmacology; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0952-3278; 1532-2823
• DOI: 10.1054/plef.2001.0294

Two currently available edible oils–olive and canola–and two oil blends of plant origin having different n-3/n-6 polyunsaturated fatty acid (PUFA) ratios were evaluated for their ability to modify vascular dysfunction in the spontaneously hypertensive rat (SHR). Synthetic diets supplemented with test oils (5% w/w) were fed for 12 weeks, and segments of thoracic aorta used to assess vascular function. Vessels from the SHR displayed a spontaneous constrictor response after the inhibition of endothelial cell nitric oxide (NO) with Nω-nitro-L-arginine (NOLA). Dietary α -linoleate enrichment led to a reduction (P