Antimicrobial resistance in Enterobacteriaceae in Brooklyn, NY: epidemiology and relation to antibiotic usage patterns

In November 1997, all Enterobacteriaceae isolated at 15 hospitals in Brooklyn were collected. Extended-spectrum β-lactamases (ESBLs) were present in 44% of 409 Klebsiella pneumoniae isolates. Six isolates had reduced susceptibility to carbapenems, including two that were not susceptible to any of th...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2000-06, Vol.45 (6), p.895-898
Main Authors: Saurina, Guillermo, Quale, John M., Manikal, Vivek M., Oydna, Elise, Landman, David
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
beta-Lactamases - metabolism
Biological and medical sciences
Drug Resistance, Microbial
Drug Utilization
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - enzymology
Humans
Klebsiella pneumoniae
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - enzymology
Medical sciences
Microbial Sensitivity Tests
New York City - epidemiology
Pharmacology. Drug treatments
Proteus mirabilis
Proteus mirabilis - drug effects
Proteus mirabilis - enzymology
USA, New York
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Summary:In November 1997, all Enterobacteriaceae isolated at 15 hospitals in Brooklyn were collected. Extended-spectrum β-lactamases (ESBLs) were present in 44% of 409 Klebsiella pneumoniae isolates. Six isolates had reduced susceptibility to carbapenems, including two that were not susceptible to any of the antibiotics tested. Pulsed field gel electrophoresis revealed a commonality of resistant isolates within and between hospitals. The occurrence of ESBLcontaining isolates was associated with cephalosporin usage (P = 0.055). ESBLs were present in 4.7% of Escherichia coli and 9.5% of Proteus mirabilis isolates. It is concluded that ESBL-producing Enterobacteriaceae are endemic in Brooklyn, are spread between hospitals, and may be associated with cephalosporin usage.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/45.6.895